Chromosomal rearrangements in acute myeloid leukemia (AML)
نویسندگان
چکیده
E Belloni, M Trubia, P Gasparini, C Micucci, C Tapinassi, S Confalonieri, P Nuciforo, B Martino, F Lo-Coco, PP Di Fiore and PG Pelicci Istituto Europeo di Oncologia, Milan, Italy Campus IFOM-IEO, Milan, Italy Divisione di Ematologia, Azienda Ospedaliera Bianchi-Malacrino-Morelli, Reggio Calabria, Italy Università di Roma Tor Vergata, Department of Biopatologia e Diagnostica per Immagini, Rome, Italy Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita' degli Studi di Milano, Milan, Italy
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Chromosome band 1 1 q23 is frequently involved in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) de novo, as well as in myelodysplastic syndromes (MDS) and lymphoma. Five percent to 15% of patients treated with chemotherapy for a primary neoplasm develop therapy-related AML (t-AML) that may show rearrangements, usually translocations involving band 1 1 q23 or, less often, 2...
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Background: The human AML1 gene, located on chromosome 21, can be fused to the AML1- eight-twenty-one (ETO) oncoprotein on chromosome eight, resulting in a t(8;21)(q22;q22) translocation. Acute myeloid leukemia (AML) associated with this translocation is considered a distinct AML with a favorable prognosis. Due to the various incidences of the translocation, which is associated with geographic ...
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